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For example, mice exposed to e-cigarette vapor created by both low and high temperatures had increased macrophage counts(83), however mice exposed to e-cigarette vapor from higher temperature (250C vs 190C) coils had decreased alveolar macrophages and less pro-inflammatory cytokines(84), and older (more used) e-cigarette coils resulted in increased inflammation(85)

Impaired healing may cause permanent bone loss in extraction sites, complicating future dental reconstruction procedures