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Children experimenting with e-cigarettes are by and large those who are already experimenting with cigarettes or are smokers. The surgeon generals report said e-cigarettes are the most commonly used tobacco product among the young and are more popular than cigarettes, cigars and hookahs in the US

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In this process, p62 interacts with the Nrf2 binding site on Keap1 to promote the release of Nrf2 from Keap-1, which subsequently activates the transcription of Nrf2 target genes (Ichimura et al., 2013)

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