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Sixty adult male NMRI mice were randomly divided into six groups and each group contained 10 mice and grouped as follows: Group I (Control group), each mice of this group neither received SIL nor nicotine but received intraperitoneal (IP) 0.2 ml/kg of 0.9% saline water as placebo for 28 consecutive days once daily to examine their morphological, biochemical, and histopathological parameters as the reference comparable values