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Smoking behavior and coffee consumption have been shown to play a key role in clozapine metabolism in previous studies ( In our MR study, we observed significant genetic evidence that smoking initiation and coffee consumption were associated with decreased concentration of clozapine and norclozapine, which enhances the evidence to establish a negative association between smoking and coffee with clozapine metabolism

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Even though overall smoking rates are declining in the general population, vaping and e-cigarettes are becoming more popular, especially among young people