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Withdrawal symptoms include: Headache Anxiety Nausea Vomiting Fatigue Tremor Sleep disturbances Depression Delirium/ illusions Mild abdominal pain Sweating Muscular cramps Irritability Loss of appetite Slurred speech Dangers Deliberate inhalation of butane can instantly kill and there is no way to avoid this

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A transcriptomic analysis between primary oral and bronchial models following e-cigarette aerosol exposure showed that bronchial epithelium was more sensitive than oral tissue but recovered quicker suggesting a tissue-specific response through distinct molecular pathways [23]