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Prior research indicates that reducing nicotine content could help smokers quit, but there is little evidence to demonstrate if these policies could adversely affect smokers with current or prior affective disorders like depression and anxiety disorders which affect an estimated 38% of U.S

After accounting for socioeconomic status and other factors, researchers at University College London estimated the loss of life expectancy per cigarette at about 17 minutes for men and 22 for women

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About 22 percent said if regulations limited the customizability of devices, such as features allowing users to adjust nicotine dose or vapor temperature, they would use e-cigs less and smoke more tobacco cigarettes