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This work was supported in part by Grants-in-Aid from Scientific Research (C) (17K09673, 26460075) from JSPS KAKENHI, Scientific Research on Innovative Areas (16H01367 and 17H05513) from a MEXT (Ministry of Education, Culture, Sports, Science and Technology), Japan, GlaxoSmithKline research grant (2016), and AMED under Grant Number, JP18gm0910013

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