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Inside a palatial white and gray brick faade, the 13,600-square-foot mansion houses 11 bedrooms, 10 full bathrooms, five half-baths, and ornate living areas that include a smoking room with a built-in bar, a wood-paneled library, and a dining room lined with rose bushes painted by San Francisco artist Al Proom

Although the insulas role in interoceptive monitoring has been well characterized [80] and higher nAChR availability in the thalamus, PFC, and cerebellum has been positively correlated with increased pain sensitivity among abstinent smokers [96], relatively little neuroimaging work has focused on the neurobiological processes that may contribute to smoking- or withdrawal-related pain dysregulation

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