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In vitro mouse MCs, ex vivo human skin explants, and in vivo murine models have demonstrated that pharmacological activation of GluK2 significantly inhibits MCs degranulation as well as cutaneous inflammatory and pruritic responses, supporting its potential as a negative regulatory therapeutic target (138)

The findings from the 2016 surgeon general report reinforce the need to support evidence-based programs to prevent youth and young adults from using tobacco in any form, including e-cigarettes, said Sylvia Burwell, then-secretary of the U.S

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