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For example, Article XVIII of the Massachusetts Bill of Rights urged a constant adherence to piety, justice, moderation, temperance, industry and frugality [which] are absolutely necessary to preserve the advantages of liberty. Legislators and magistrates must exercise an exact and constant observance of those principles in the formation and execution of the laws. None other than John Adams had drafted that document in the Massachusetts convention

Children of mothers who sustained smoking during pregnancy had an increased risk of bronchial asthma at 3 years of age even after adjusting for pre- and postnatal covariates (adjusted odds ratio [aOR] 1.34, 95% confidence interval [CI] 1.151.56)

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This is one of the greats, whos still trying and exploring, and doing it very publicly