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Briefly, ten mice in COPD group were exposed to five cigarettes (Nanning Jiatianxia unfiltered cigarettes, 12 mg of tar and 0.9 mg of nicotine) four times per day with 30 min smoke-free intervals in a closed 0.75-m 3 room, 5 days per week for up to 12 or 24 weeks

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This is why its important to use trazodone only under a doctors supervision and follow the prescribed dosage