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I guess my biggest concern using any type of plastic in a high pressure type of environment like this is that some leaching of the plastic chemicals could occur and this may just be my own conspiracy theory (or paranoia) but, I have a feeling that today's high cancer rate has less to do with (pure) tobacco and more to do with the amount of plastics we now use in our every day lives around consumables

Methyl donor micronutrients that modify DNA methylation and cancer outcome

A randomized controlled trial of oral selegiline plus nicotine skin patch compared with placebo plus nicotine skin patch for smoking cessation

Definitely a long time favorite