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Since the lower esophageal sphincter is composed of smooth muscle, the intake of nicotine during smoking can cause the muscle to relax and function improperly

Drug-Disease Interactions NICOGUM 4 FRESH MINT FLAVOURED SUGAR FREE NICOTINE GUMS 12 interacts with the following diseases: Heart Disease : Individuals with heart disease should be cautious as the nicotine in the gum may increase heart rate and blood pressure

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