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New Legal Age to Purchase Tobacco Products Now 21 Age restrictions for the purchase of tobacco products have been slowly shifting over the years, with Hawaii being the first state to legally raise the age to 21 in 2015 and California following suit in 2016

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If no pathogenic variant is found, the search for the recurrent COL1A1 p.(Arg312Cys) variant should be performed [1, 6, 16]

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