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The FDA said in April 2024 it had issued more than 100 warning letters to retailers warning against the sale of Zyn products and other nicotine pouches to children

A Cochrane review of interventions for tobacco use cessation among people in treatment for or recovery from substance use found that offering pharmacotherapy for smoking cessation increased tobacco abstinence (risk ratio RR = 1.88, 95% CI 1.352.57), as did combined counselling and offering pharmacotherapy for smoking cessation (RR = 1.74, 95% CI 1.392.18) compared with usual care or no intervention

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