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The median overall survival in the traditional chemotherapy group (methotrexate, docetaxel, or cetuximab) was 6.9 months, which was lower than that in the pembrolizumab treatment group (8.4 months) [37]

Additionally, in 2023, the most recent year for which such data are available, an estimated 48.6 million US adults reported using any tobacco product (e.g., cigarettes, cigars, and pipes) (188)Arrazola RA, et al

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