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Start in Chicago, visit the many great dunes along Michigans western shore (such as Nordhouse for peace and quiet and Sleeping Bear for majestic beauty), take a detour to Mackinac Island, see Pictured Rocks National Lakeshore and the Porcupine, and even consider tacking on the Apostle Islands, Door County, or Green Bay

Particularly, EMT can be induced by TGF- through the activation of PI3K/AKT and MAPK in the Smad-independent pathway [122,123,124]