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Under Excretion: There are two ways of looking at high uric acid levels: Someone can create too much uric acid (genetics and/or diet) Someone can have problems excreting uric acid The third phenotype here is a combination of both creating too much uric acid along with not excreting enough.[ref] Figuring out which genetic variants you carry that impact these pathways may help you determine the best method of decreasing uric acid levels personalized for you