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In vitro mouse MCs, ex vivo human skin explants, and in vivo murine models have demonstrated that pharmacological activation of GluK2 significantly inhibits MCs degranulation as well as cutaneous inflammatory and pruritic responses, supporting its potential as a negative regulatory therapeutic target (138)

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The look was basically a phone and an ashtray. While making Twin Peaks: The Return, Lynch would usually come home from work at dawn, when his fourth wife and young daughter were just starting their day

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