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Some of the tests they may run include: Testing blood or urine to identify infections, indicate blood vessel damage or find toxins that affect the nervous system Testing the cerebrospinal fluid (fluid that surrounds the brain and spinal cord) to detect infections or bleeding in the skull or measure excess pressure in the skull Imaging, like CT or MRI, to check if there are physical abnormalities that may be contributing to your headache Headache treatment options Depending on your diagnosis, your doctor may prescribe medication or recommend lifestyle changes for your headache care