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Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E: Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule

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While the exact reasons or combination of reasons for this is not fully understood, factors are likely to include: An impact of bowel motility/bowel movements The ability of alcohol to damage the gut lining via oxidative stress Impact on the gut microbiome [Source: Pubmed] It has also been reported those that who consume alcohol have an increased risk of experiencing bleeding as a form of diverticular complications