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Public health and anti-tobacco groups criticized the plan as not going far enough to stem an emerging public health threat

lncRNA: long non-coding RNA LP: Lamina propria MIF: Macrophage migration inhibitory factor MtTFA: Mitochondrial transcription factor MMP14: Matrix metalloproteinases 14 MUC5AC: Mucin 5AC, oligomeric mucus/gel-forming PRMT6: Protein arginine methyltransferase 6 PMVECs: Pulmonary microvascular endothelial cells PBS: Phosphate buffered saline RPMECs: Rat pulmonary microvascular endothelial cells Rbm: Reticular basement membrane ROS: Reactive oxygen species RLMVECs: Rat lung microvascular endothelial cells RAGE: Receptor for advanced glycation end products SPDEF: SAM-pointed domain-containing Ets-like factor TNF-: Tumor necrosis factor- rhTNFR: Fc: Recombinant human tumour necrosis factors receptor Fc fusion protein TLR4: Toll-like receptor 4 TGF-1: Transition transforming growth factor-beta 1 TSE: Tobacco smoke extract VEGFA: Vascular endothelial growth factor A VEGF: Vascular endothelial growth factor

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The growth in the historic period can be attributed to growing awareness of smoking health risks, increasing popularity of nicotine alternatives, rising disposable income, urbanization and lifestyle changes, aggressive marketing by e-cigarette brands