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Although nicotine is recognized as a component responsible for adverse vascular effects caused by cigarette smoking, several lines of evidence show that nicotine-free cigarette smoke extract (N()-CSE) substantially impairs endothelial NO-dependent relaxation [4,5,6]

There are other flavors that can be picked out: leather, espresso and oak, along with a slight earthy note, but the harshness is pervasive and only gets stronger as the cigar burns down

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