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[19] [20] Synthetic derivatives of nicotine, such as varenicline, act as partial agonists at nicotinic receptors and are also used as smoking cessation aids

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Smoking and cholesterol are not a good match when it comes to staying healthy

In a significant move, the FDA authorized the marketing of 20 Zyn products in early 2025, deeming them appropriate for the protection of public health based on lower toxicant levels compared to cigarettes and evidence supporting complete switching among some adult smokers, while imposing strict marketing restrictions to limit youth appeal (19)