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Alcohol itself boosts dopamine levels in the brains pleasure centres, which causes a feeling of euphoria but at the same time also dampening your response to that new high (you basically get used to it)

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Meta-analyses have summarized this work, and the popular figures used by policymakers and the World Health Organization are a PED of 0.4 in high-income countries and a PED of 0.8 in low- and middle-income countries

We also thank the High-Performance Computing center of Peking University Institute of Advanced Agricultural Science, Shandong Laboratory for Advanced Agricultural Sciences for providing computational resources in this work