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This work is supported by the National Institutes of Health [1R01CA260459-01] and the National Cancer Institute and Food and Drug Administration Center for Tobacco Products [#U54CA180905].

Cigarette smoking has been the major issue in public health for the last 70 years, and the goal is to get [to] a smoke-free society, said study co-author John Pierce, also a professor at the Herbert Wertheim School and a member of Moores Cancer Center

Damage to the lungs and a deterioration in lung function are directly related to the number of packs of cigarettes a person typically smokes per day times the number of years the person has smoked, a measure known as pack years

While the research suggested that substance initiation in adolescents can progress to additional substance use, the stability of substance use over time varies