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Therefore, in supplementary sensitivity analyses to further test robustness of the lifetime smoking results, we concatenated independent instrument sets for lifetime smoking and, alternatively, CAD using the CARDIoGRAMplusC4D-UK Biobank CAD (Coronary ARtery DIsease Genome wide Replication and Meta-analysis (CARDIoGRAM) plus The Coronary Artery Disease (C4D) Genetics) GWAS meta-analysis 74,75