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Additionally, the heritability of the clinical phenotype of nicotine dependence remains consistent (~50%) across multiple studies, assessment measures, and cultures as does the heritability of volumetric tobacco consumption is also estimated at about 50%

High-nicotine products, like nicotine salt systems and disposables such as the Hayati Pro Max Plus 6000, sold in a box of 5 units, deliver more nicotine per puff than freebase liquids (312 mg/mL vs

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