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Nicotine is the most addictive substance contained in cigarettes

The plastic cellulssose acetate filter and paper modify the particulate smoke phase by particle retention (filtration), and finely divided carbon modifies the gaseous phase (adsorption)

Sample size calculations were based on preliminary Dyspnoea-12 score differences with an anticipated effect size of d=0.5, derived from preliminary data and previous literature on respiratory symptoms in young adult populations 16,17 , alpha level of 0.05, and power of 1-=0.90, accounting for a 10% attrition rate, yielding a requirement of approximately 60 participants per group