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2010;6 doi: 10.1371/journal.ppat.1000713

[16] History, society and culture [edit] "Aphthous affectations" and "aphthous ulcerations" of the mouth are mentioned several times in the treatise "Of the Epidemics" (part of the Hippocratic corpus, in the 4th century BCE), [25] although it seems likely that this was oral ulceration as a manifestation of some infectious disease, since they are described as occurring in epidemic-like patterns, with concurrent symptoms such as fever

Tremors begin, heart rate increases significantly, and breathing becomes rapid