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Nicotine pouches and gum health conclusions While unconfirmed, the data suggest that nicotine pouches may pose gum health risks for the following reasons: Nicotine can be cytotoxic (cause cell death) at higher concentrations Nicotine is capable of both pro- and anti-inflammatory effects depending on the concentration level (and under different conditions) Nicotine constricts blood vessels, which may promote and exacerbate gum disease and recession Gum recession is a known side effect of snus, which shares some similarities with nicotine pouches There are concerns that other ZYN ingredients (such as flavorings) could negatively impact oral health Although its unlikely that ZYNs are a direct cause of gum disease, those with poor gum health would be advised to proceed with caution

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Finally, AHAM asserts conflicts with Canadian test procedures could cause further confusion

The plain packaging rules do, however, still face a number of challenges under global trade rules