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In the past, the makers of cigarettes like American Spirit have relied on strikingly similar terms to market their products as additive free, natural, or simple. Because these descriptions made American Spirit cigarettes appear to be a healthier alternative to other cigarettes, the FDA required marketing copy for American Spirit to remove the terms additive free and natural. Similarly, terms like tobacco-free in oral nicotine marketing could suggest products are healthier and lower risk to consumers

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1A) identified five genome-wide significant loci (Fig