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Skin Features of Each Type of EDS Hypermobile EDS (hEDS) Common skin features Soft, mildly stretchy skin Mild atrophic scarring Stretch marks Classical EDS (cEDS) Common skin features Extensive skin involvement, usually apparent from a very young age Very soft, stretchy, fragile skin Severe atrophic scarring Doughy skin texture Easy bruising Molluscoid pseudotumors Subcutaneous spheroids Vascular EDS (vEDS) Common skin features Easy bruising Thin, translucent skin with increased venous visibility Premature aging Periodontal EDS (pEDS) Common skin features Skin hyperextensibility Skin fragility Wide or atrophic scarring Easy bruising Premature aging Prominent vasculature Kyphoscoliotic EDS (kEDS) Common skin features Skin hyperextensibility Easy bruising Skin fragility Delayed wound healing Spondylodysplastic EDS (spEDS) Common skin features Skin hyperextensibility Soft and doughy Thin and translucent skin Brittle cornea syndrome (BCS) Common skin features Soft, velvety, and/or translucent skin Skin hyperextensibility Arthrochalasia EDS (aEDS) Common skin features Skin hyperextensibility Atrophic scars Easy bruising Musculocontractural EDS (mcEDS) Common skin features Skin hyperextensibility Easy bruising Skin fragility with atrophic scars Increased palmar wrinkling Classical-like EDS (clEDS) Common skin features Skin hyperextensibility and velvety skin texture without atrophic scarring Easy bruising Dermatosparaxis EDS (dEDS) Common skin features Extreme skin fragility with congenital or postnatal tears Progressively redundant, almost lax skin with excessive skin folds at wrists and ankles Increased palmar wrinkling Severe bruising with risk of subcutaneous hematoma Soft and doughy skin texture Skin hyperextensibility Atrophic scars Myopathic EDS (mEDS) Common skin features Soft, doughy skin Atrophic scarring Cardiac-valvular EDS (cvEDS) Common skin features Skin hyperextensibility Soft skin Atrophic scarring Easy bruising Delayed wound healing Thin skin

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