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Alterations to CYP450 enzyme function and drug interactions Cytochrome P450 (CYP450) enzymes play a critical role in drug metabolism, especially for therapeutic compounds used to treat symptoms associated with depression and other psychiatric disorders

5 In another study of adolescents, e-cigarettes were associated with an increased risk of cracked or broken teeth, or tongue/oral mucosal pain

While previous data placed the split around the 16th century 25 , both of our models suggest it occurred long before the first peoples arrived in New Zealand (approximately 1,250 CE)