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Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke
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Future research should consider focusing on (1) identifying factors that could strengthen or weaken these relationships (e.g., moderation of these effects by family factors), (2) engaging in lengthier longitudinal research (with greater than 1-year gap between the predictive and outcome variables) to better understand the timing and specific influences of the relationships found in the current study and examine patterns of use over time, (3) conducting a Latent Profile Analysis (LPA) of these and other potentially predictive factors with a categorical outcome of being either a lifetime user or past 30-day user in order to identify which youth are predisposed to membership in the riskier past 30-day use group, and (4) promoting utilization of prevention programs or interventions that target these youth factors in an effort to decrease co-use and stave off age at first use
