tobacco effects on urinary system Sub-acute administration of lower doses of nicotine caused sex-dependent improvement of renal function in Wistar rats The Many Dangers of Tobacco

(wikipedia) Theme is simple, but resulting theme answers (and clues) are funny, so I approve

Signal has built their Menthol lineup with a filter that suffices to expunge any unwanted byproducts of combustion when ignited, leaving the smoker with a pure taste and an aromatic room note that attracts positive attention

And that was 1958

Van Akkooi, AC, Hieken, TJ, Burton, EM, Ariyan, C, Ascierto, PA, Asero, SV, Blank, CU, Block, MS, Boland, GM, Carac, C, Ch'Ng, S, Davidson, BS, Duprat Neto, JP, Faries, MB, Gershenwald, JE, Grunhagen, D, Gyorki, DE, Han, D, Hayes, AJ, Van Houdt, WJ, Karakousis, G, Klop, WM, Long, GV, Lowe, MC, Menzies, AM, Olofsson Bagge, R, Pennington, TE, Rutkowski, P, Saw, RP, Scolyer, RA, Shannon, K, Sondak, V, Tawbi, H , Testori, A, Tetzlaff, M, Thompson, JF, Zager, JS, Zuur, CL, Wargo, J, Spillane, A, Ross, MI