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Common side effects of this medicine include nausea (feeling sick), headaches, abnormal dreams, difficulty sleeping, increased appetite, altered taste sensation, dry mouth, dizziness, tiredness and sleepiness, vomiting, constipation, diarrhoea, feeling bloated, indigestion and flatulence

King James Is 1604 treatise A Counterblaste to Tobacco called tobacco a filthie noveltie that was hatefull to the Nose and harmefull to the braine. He wasnt wrong: the nicotine in tobacco binds to receptors in multiple regions of the brain, raising dopamine levels and mimicking a key neurotransmitter that affects focus and arousal

Legally is the operative word there