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Peer review Peer review information Nature Human Behaviour thanks Ram Bajpai and Olga Perski for their contribution to the peer review of this work

In addition to standard investigational medicinal product requirements, NP-based formulations entering clinical development must provide detailed manufacturing parameters and comprehensive physicochemical characterization, as in vitro quality attributes do not necessarily predict in vivo behavior ( 3.9 NP type diversity and public acceptance A wide range of NPbased drug delivery systems have been investigated for IBD, each characterized by distinct physicochemical properties, therapeutic efficiencies, and safety profiles ( Table 2 ) ( In summary, while nanomaterials hold significant promises for drug delivery, diagnostics, and targeted therapiesparticularly for chronic GI conditionscritical challenges remain, including large-scale production, manufacturing consistency, and ensuring long-term product stability (Korsmeyer, 2016