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This confirmed that CR was significantly enriched within tumor tissue compared with levels in immediately adjacent (Supplemental Figure 1G) as well as noninvolved, nontumor (Figure 1, C and D) tissue, thus significantly correlating with our quantitative LC-MS/MS assay (Supplemental Figure 1, D and E) and further supporting the assertion that urinary CR is a surrogate measure of the intratumoral CR concentration

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