By contrast, when a cigar is exposed to extremely high humidity, it can lead to mold, rot, and even an infestation of tobacco beetles (thats right, beetles)
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For instance, acrolein has been found to inhibit CYP450 enzymes (173), and formaldehyde specifically reduces the levels of CYP2C11, CYP2E1, and CYP3A2, but increases CYP1A2, in male rats (166)