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[18] Cultural references [edit] The fictional detective Sherlock Holmes frequently smokes large amounts of shag tobacco in pipe form while pondering the details of a case, leaving the air thck with smoke

"It really damages the blood vessel lining and it accelerates the development of plaques and coronary artery disease." Smoking is also linked to heart rhythm issues, such as atrial fibrillation and stroke, Maio added

Supplementary information Supplementary Tables 127, Figs

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