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Its also possible that the extensive public education and increased public awareness that accompanied the 2019 e-cigarette or vaping product use-associated lung injury (EVALI) outbreak may have played a role. The authors noted, however, that while some of these factors might have contributed to changes in e-cigarette use, this study did not determine if factors, such as legislation, actually had an impact

This is the case, for example, for certain tobacco alkaloids such as anabasine or anatabine but also molecules called tobacco nitrosamines

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