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doi:10.3390/cells13161330 70

The researchers said they embarked on this study because of a trend of people smoking fewer cigarettes rather than quitting

With long-term smoking exposure, the DNA sequence suffers persistent miscoding that triggers epigenetic changes in various vital oncogenes, such as NOTCH1 , ATK3 , DUSP4 , SMAD6 , and S MARCA4 , in the major enriched pathways (see Fig