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Albuterol is longer acting than isoproterenol in most patients by any route of administration because it is not a substrate for the cellular uptake processes for catecholamines or for COMT Less than 20% of a single albuterol dose is absorbed systemically following nebulizer administration Albuterol does not readily cross the blood brain barrier Bronchodilation is maximal in ~15 minutes, and persists for 3-4 hours

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DOI: 10.1016/j.conb.2016.12.012 Kalaria RN, Harik SI (1987): Blood-brain barrier monoamine oxidase: enzyme characterization in cerebral microvessels and other tissues from six mammalian species, including human