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The lower Parkinsons rates in smokers may be driven by genetic factors, by other compounds in tobacco smoke (not nicotine specifically), or again by survivorship bias

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Other common signs of depressant abuse include: Reduced energy A dip in productivity Depression or apathy The inability to stop using a depressant Withdrawal symptoms when you go without the depressant Dramatic mood swings Erratic or secretive behavior Be aware that abusing depressant drugs can cause serious, life-altering complications