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Abbreviations: AM (alveolar macrophage), BAL (bronchoalveolar lavage), DC (dendritic cell), e-cig (e-cigarette), e-cig vaped extract (EVE), gen (generation), h (hour), min (minute), NK (natural killer), PG (propylene glycol), THC (tetrahydrocannabinol), VG (vegetable glycerin) The long-term effects of e-cigarette use in humans remain to be seen but it is possible that epithelial damage from flavored, nicotine-containing e-cigarettes will lead to airway remodeling, increased mucous production, decreased ciliary function, and airway obstruction, which is similar to pathophysiology seen in COPD caused by conventional cigarettes

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Pods leak the odd time especially with some particular juices but its a minor issue