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Thirdhand aerosol is the mixture of chemicals in e-cigarette/vape pen aerosol that remain on surfaces and in dust, even after the aerosol is gone, and react with other chemicals in the environment to form toxic chemicals

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however, in the 1960s, chemists working at the tobacco company Philip Morris discovered that if tobacco is treated with an alkaline solution (e.g., ammonia-based), nicotine is converted to a much more volatile free base (more than 100 times), which greatly increases its absorption in the lungs and brain