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14 demonstrated that both drug cues and energy-dense foods recruit the dopamine motive system, driving heightened motivation, cue-reactivity, and compulsive reward seeking across substance and food addiction phenotypes

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As Michael Russell famously put it, People smoke for the nicotine, but they die from the tar. 1 In its February 2020 presentation on its products to an FDA Tobacco Products Scientific Advisory Committee panel, 22nd Century Group clearly states, VLN cigarettes yield essentially the same HPHCs as conventional cigarettes

3 There is no safe level of smokeless tobacco use and there are several negative health consequences from smokeless tobacco use