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Human twin studies and animal research demonstrate that these genes significantly influence smoking behavior, nicotine dependence, and quit success by controlling how nicotine interacts with the brains reward system, particularly in the dopaminergic cells of the ventral tegmental area and nucleus accumbens These genetic factors make certain people more likely to develop tobacco dependence compared to others

A review of the evidence on smoking and alcohol use among police officers pointed to a study from the late-1980s showing that police officers have one of the highest smoking rates of all professions in the U.S

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