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"As our oversight and scientific knowledge of tobacco products has evolved, so too should our requirements for manufacturers and importers to provide information about the chemicals or chemical compounds in their products that cause or could cause harm to users and nonusers," acting FDA Commissioner Ned Sharpless said in a statement

Genera such as Stenotrophomonas and Schlegelella dominated the oral cancer microbiome of Toombak users, potentially contributing to metastasis and poor prognosis, highlighting microbiome modulations as a risk factor for oral cancer progression [78]

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